ATORVASTATIN

Product Description

DAYARAM PHARMA CHEM is among world’s top most manufacturer,supplier, exporter and trader of the Atorvastatinfinished formulations moreover Atorvastatin API. DAYARAM PHARMA CHEM is thehuge manufacturer, exporter and supplier of Atorvastatin API and formulationsituated in Ankleshwar, Gujarat, India.

DAYARAM PHARMA CHEM is the manufacturer, exporter andsupplier of Atorvastatin API and Atorvastatinin all over the world.

Ourproduct Atorvastatin is world widelyappreciated by our group companies and clients. We give best possible sellingprice of Atorvastatin to our clients, because customer satisfaction is our toppriority.

DAYARAM PHARMA CHEM exporting the Atorvastatin API, Intermediates andfinished formulation internationally from many years in countries like PuertoRico, United States, Philippines, New Zealand, Sri Lanka, Canada, UnitedKingdom, Finland, Ireland, Jordan, Indonesia, Singapore, Sweden, Germany,Australia, Switzerland, Vietnam, Iraq, United Arab Emirates, Bangladesh,Denmark, Malaysia, Kenya, Austria, Norway, Nigeria, Hungary, Hong Kong, SaudiArabia, Pakistan, Slovakia, Thailand, South Korea, Argentina, South Africa,Iran, Czechia, Israel, Taiwan, Greece, Egypt Romania, Netherlands, Turkey,Poland, Mexico, Spain, France, Italy, Brazil, Japan and many other countries.

DAYARAM PHARMA CHEM also supply the Atorvastatin API, Intermediates andfinished formulations in all Indian states like Gujarat,Maharashtra, Punjab, Delhi, Tamilnadu, Goa, Uttar Pradesh, Karnataka, Jammu& Kashmir, West Bengal, Assam, Rajasthan, and Hyderabad Etc.

Atorvastatin is one type of statin medicationwhich is used to prevent the cardio vascular disease. Atorvastatin is a firstline medication which is used in treatment of cardio vascular disease.Atorvastatin belongs to the HMG-CoA reductase inhibitors class of medicine.

SYNOYMS: Atorvastatin,torvastatina, atorvastatine, atorvastatinum.

IUPACNAME OF ATORVASTATIN: (3R, 5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoicacid

CASNO: 134523-00-5

MOLECULARFORMULA: C₃₃H₃₅FN₂O₅

MOLECULARMASS: 558.64 g/mol

STORAGECONDITION: Store the medication in its original container.  Store it in a dry place at a room temperature,away from light and moisture. Do not put medication in bathroom, fridge or inkitchen. Keep it away of reach of children and pet.

HOW TOUSE ATORVASTATIN: Take the medication by mouth withor without food one time per day. In case of any confusion ask your doctor foradvice.

Take medication regularly for the better result, do not miss thedose.

HOW ATORVASTATINWORKS: Atorvastatininhibits the production of cholesterol in the body, by this the amount ofcholesterol will decreased. Because of the high cholesterol, it will build upwalls of fat in the arteries and blocks the flow of blood that cause high bloodpressure.

PHARMACOKINETICSOF ATORVASTATIN: Atorvastatin will rapidly absorbafter the oral administration. Atorvastatin reach the peak plasma concentrationin about 1-2 hrs.

The normal volume of distribution of Atorvastatin is likely380litre. The half-life of Atorvastatin is about 14hrs and the metabolites ofAtorvastatin can reach up to 30hrs.

Atorvastatin is primary excreted by biliary excretion. Very lessamount like 2% is recovered by the urination.

SIDE EFFECTS: There are some effects likememory loss and problem in remembering is common. The other effects likeconfusion, weakness, muscle pain, and kidney problems if these type of effectsseen contact your doctor. Atorvastatin can worsen the diabetes, so kindly talkto your doctor about the risks. There are other allergic reactions like rash,itching, swelling can also see in some patients.

PRECAUTIONS: Atorvastatin medication must notbe taken in the pregnancy because it can harm the baby. Kindly tell your doctorabout your past disease like kidney, heart problem, and liver problem lung problembefore writing the prescription.taking alcohol along with this medicine cancause liver problem, so kindly avoid taking alcohol.

CDSCO APPROVAL: S (-) Metoprolol 25mg/50mg (ER) +Atorvastatin (IR) 10mg tablets approved by CDSCO in India in 01.04.2010,

 Atorvastatin 10mg +Ramipril 5mg + Aspirin (EC pellets) 75mg/150mg + Metoprolol (ER tablets) 25mgCapsules approved by CDSCO in India in 05.04.2010,

 Atorvastatin (40mg) +Ezetimibe (10mg) Tablet (addl. Strength) approved by CDSCO in India in 30.07.2007,

 Atorvastatin + Fenofibrate approvedby CDSCO in India in 24.12.2004,

Telmisartan 40mg + Atorvastatin (as calcium) 10mg Tablets approvedby CDSCO in India in 22.05.2008,

Atorvastatin calcium (amorphous) approved by CDSCO in India in 27.05.2005,

 Atorvastatin Calcium (10mg)+ Ramipril (2.5mg/5mg) tablet approved by CDSCO in India in 15.10.2007,

Atorvastatin 5mg + Fenofibrate 160mg (additional strength)approved by CDSCO in India in 01.12.2006,

Atorvastatin Calcium (10mg) + Fenofibrate (145mg) (addl. strength)approved by CDSCO in India in 30.10.2007,

 FDC of atorvastatin +fenofibrate approved by CDSCO in India in 01.08.2006,

 Atorvastatin 10mg + Aspirin75/150mg Capsules approved by CDSCO in India in 18.01.2008,

Olmesartan (20/40mg) + Atorvastatin approved by CDSCO in India in 27.10.2009

Glimepiride 1/2 mg + Metformin 500 mg + Atorvastatin 10 mg tabletsapproved by CDSCO in India in 17.12.2009,

 Atorvastatin +Metformin(10mg + 500mg SR) Tablets approved by CDSCO in India in 04.12.2008,Atorvastatin 10mg + Fenofibrate 80mg tablet (Additional Indication) approved byCDSCO in India in 25.01.08,

 Atorvastatin calciumtablets approved by CDSCO in India in 17-09-1999,

Metoprolol Succinate Equivalent to Metoprolol Tartrate [ER25/50mg] + Atorvastatin (As calcium) 10mg tablets approved by CDSCO in India in28.01.08,

 Atorvastatin + Ezetimibetabs approved by CDSCO in India in 13/08/2004,

Atorvastatin calcium 5mg/10mg/20mg/40mg/80mg (Additional DosageForm) approved by CDSCO in India in 20.04.11,

 FDC of Atorvastatin (10mg)+ Niacin (375mg/500mg E.R) Capsule approved by CDSCO in India in 26/07/2005,

 Amlodipine besylate +Atorvastatin tablets approved by CDSCO in India in 11/02/2004,

 Atorvastatin Calcium 80mgtablets (Additional Strength) approved by CDSCO in India in 25.02.08,

S(-) amlodipine + Atorvastatin approved by CDSCO in India in10/02/2004,

Atorvastatin approved by CDSCO in India in 30/10/2001,

 Atorvastatin 20mg +Ramipril 2.5mg/5mg Capsules approved by CDSCO in India in 17.03.10.

FORMULATIONS AVAILABE IN MARKET:

Atorvastatin 5mg Tablets

Atorvastatin 10mg Tablets

Atorvastatin 20mg Tablets

Atorvastatin 30mg Tablets

Atorvastatin40mg Tablets

Atorvastatin 80 mg Tablets

Atorvastatin Calcium (10mg) + Ramipril (2.5mg/5mg) tablets

S(-)Metoprolol 25mg/50mg (ER) + Atorvastatin (IR)10mg tablets

Atorvastatin 10mg + Ramipril 5mg + Aspirin (EC pellets) 75mg/150mg+ Metoprolol (ER tablets) 25mg Capsules

Atorvastatin + Fenofibrate

Telmisartan 40mg + Atorvastatin (as calcium) 10mg Tablets

Atorvastatin calcium (amorphous)

Atorvastatin 5mg + Fenofibrate 160mg (additional strength)

Atorvastatin Calcium (10mg) + Fenofibrate (145mg) (addl. strength)

Olmesartan (20/40mg) + Atorvastatin tablets

Atorvastatin + Metformin (10mg + 500mg SR) Tablets

FDC of Atorvastatin (10mg) + Niacin (375mg/500mg E.R) Capsule

Amlodipine besylate + Atorvastatin tablets

Atorvastatin Calcium 80mg tablets (Additional Strength

Atorvastatin 20mg + Ramipril 2.5mg/5mg Capsules

Note: Product protected by validpatents are not offered for sale in countries where such patents are stillvalid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult